Table 2. mRNA levels of components of the renin-angiotensin system in WT and ACE2 KO mice after sham operation or I/R.
Components | WT sham (n = 5) | ACE2 sham (n = 5) | WT IR (n = 7) | ACE2 IR (n = 6) |
ACE | 0.70±0.06 | 0.89±0.09 | 1.06±0.35 | 0.36±0.12 |
ACE2 | 0.74±0.04 | N.D. | 2.13±0.85 | N.D. |
Angiotensinogen | 0.69±0.06 | 1.07±0.23 | 2.37±0.69 | 0.85±0.18 |
Renin | 0.68±0.08 | 1.01±0.19 | 2.31±1.00 | 1.62±0.32 |
AT1R | 0.73±0.06 | 0.67±0.07 | 2.31±0.71 | 1.21±0.17 |
Mas | 0.68±0.12 | 0.84±0.10 | 1.14±0.33 | 0.78±0.30 |
Values are expressed as fold change versus WT sham and presented as mean ± SE. N.D., non-detectable.