Table 8. Individual and profiled gene expression effects on DFS.

	N patients	Median (mo)	SD	95% CI, low	95% CI, high	Log-rank p	Gene expression in the good prognosis signature (30-gene predictor)	Concordance (trend) with the 30-gene predictor pattern
ACE2	159					0.070	Up-regulated	YES
low	71	56.52	23.23	10.99	102.06
high	88	97.87	7.36	83.44	112.30
DHTKD1	171					0.436	Up-regulated	NO
low	85	94.46	15.75	63.60	125.32
high	86	83.77	11.86	60.52	107.02
FLOT1	178					0.068	Down-regulated	YES
low	89	100.30	12.55	75.69	124.90
high	89	80.46	26.01	29.48	131.44
MAP4K1	169					0.252	Up-regulated	YES
low	86	74.11	23.75	27.55	120.67
high	83	91.80	9.12	73.92	109.69
NEK2	156					0.366	Down-regulated	YES
low	78	94.43	7.48	79.76	109.10
high	78	69.15	18.68	32.53	105.76
PRKD1	162					0.012	Down-regulated	YES
low	81	94.46	7.75	79.28	109.64
high	81	69.15	27.42	15.41	122.89
SFRS8	184					0.400	Up-regulated	NO
low	92	91.15	17.82	56.21	126.08
high	92	87.34	11.77	64.27	110.41
TBC1D	165					0.193	Up-regulated	NO
low	82	91.15	15.67	60.44	121.85
high	82	74.11	13.92	46.82	101.40
TGOLN2	183					0.360	Down-regulated	YES
low	91	91.15	15.07	61.61	120.69
high	92	82.82	20.67	42.30	123.34
YTHDC2	176					0.149	Up-regulated	NO
low	88	97.87	15.64	67.22	128.51
high	88	80.46	19.87	41.51	119.41
ACE2/FLOT1/PRKD1	149					0.009	N/A
intermediate profile	108 (72.5%)	83.77	15.32	53.75	113.79
high/low/low	20	141.84	49.20	45.41	238.26			YES, good prognosis
low/high/high	21	13.93	8.33	0.00	30.26			YES, bad prognosis
FLOT1/PRKD1	161					0.006	N/A
intermediate profile	78 (48.4%)	91.15	6.51	78.38	103.91
low/low	42	141.84	65.83	12.81	270.86			YES, good prognosis
high/high	41	46.75	30.24	0.00	106.03			YES, bad prognosis
ACE2/PRKD1	149					0.005	N/A
intermediate profile	72 (48.3%)	87.34	16.82	54.38	120.31
high/low	36	141.84	26.43	90.03	193.65			YES, good prognosis
low/high	41	18.79	4.13	10.68	26.89			YES, bad prognosis

N/A, non-applicable.

Significant p values are shown in bold.