Figure 5. MiR-185 and 342 inhibit cell proliferation and induce apoptosis in subcutaneous xenografts.

Quantification of A, Ki67 (cell proliferation) and B, cleaved PARP (C-PARP; apoptosis) positive cells in subcutaneous C4-2B tumor specimens collected from the miR-NC, 185 and 342 treated groups. One hundred cells at 5 randomly selected areas were counted and positively staining cells were recorded. **, P < 0.005 significant differences from the control NC group. Data represent the mean ± SD. Arrowheads indicate the C-PARP positive cells. Scale bars = 100 µm.