Fig. 6.

Effects of 3K3A-APC late multiple dose therapy on newly formed neuroblasts and the cortical width index in F2r^−/− mice after dMCAO. (A) Dcx⁺/BrdU⁺ neuroblasts migrating from the subventricular zone (SVZ) to the corpus callosum (CC) (upper panels; scale bar 50 µm) and the peri-infarct region (lower panels, scale bar 50 µm) 7 days after dMCAO. Graphs showing the number of Dcx⁺/BrdU⁺ neuroblasts in the SVZ (B), corpus callosum (C) and peri-infarct area (D) 7 days after dMCAO. (E) Cortical width index 14 days after dMCAO. F2r^−/− mice on C57Bl6 background were treated with a multiple dose 3K3A-APC (0.8 mg/kg intraperitoneally at 12 h, and at 1, 3, 5 and 7 days after ischemia onset) or vehicle. Mean±SEM, n = 5 mice/group.