Table 1.

Classes of families and characteristic of pancreatic cancer affected members of BCFR

Class	BRCA1	BRCA2	3 (BRCAX)	4 (BRCAX)
Selection Criteria	Proband carrier of a BRCA1 mutation	Proband carrier of a BRCA2 mutation	Proband tested negative for BRCA1 and BRCA2 mutations; 2 or more BC >=50 years	Proband tested negative for BRCA1 and BRCA2 mutations; at least 1 BC
No. of families	538	383	1,219	3,659
No of individuals (men/women)	11,946 (5,457/6,490)	7,773 (3,502/4,271)	17,037 (7,158/9,879)	42,064 (18,461/23,603)
No. of PC cases	67 57 families: 1 PC 4 families: ≥2PC	62 42 families: 1 PC 7 families: ≥2PC	82 61 families: 1 PC 10 families: ≥2PC	206 170 families: 1 PC 16 families: ≥2PC
Gender (PC cases only)	32 males 35 females	35 males 27 females	40 males 42 females	112 males 94 females
Mean age at diagnosis of PC	65.9 years SD (14.9)	63.1 years SD (11.0)	66.9 years SD (12.7)	66.9 years SD (12.5 )

Abbreviations; BC: breast cancer, PC pancreatic cancer, SD: standard deviation