Table 3.
Estimated pancreatic cancer SIRs for BRCA1 and BRCA2 mutation carriers from the BCFR
| BRCA1 mutation carriers | BRCA2 mutation carriers | |||||||
|---|---|---|---|---|---|---|---|---|
| Obs | Exp | SIR | 95%CI | Obs | Exp | SIR | 95%CI | |
| Overall | 34.0 | 8.26 | 4.11 | 2.94-5.76 | 41.8 | 7.23 | 5.79 | 4.28-7.84 |
| Men | 14.8 | 4.79 | 3.09 | 1.86-5.15 | 22.5 | 3.88 | 5.81 | 3.84-8.78 |
| Women | 19.2 | 3.47 | 5.52 | 3.53-8.64 | 19.3 | 3.35 | 5.77 | 3.69-9.01 |
| ≤ 50 years | 5.59 | 0.72 | 7.75 | 3.38-17.7 | 5.47 | 0.55 | 9.90 | 4.28-22.9 |
| >50 years | 28.4 | 7.54 | 3.77 | 2.61-5.44 | 36.4 | 6.68 | 5.45 | 3.94-7.54 |
| FDRs | 11.2 | 2.51 | 4.47 | 2.49-8.03 | 13.6 | 2.45 | 5.55 | 3.27-9.45 |
| Population-based | 5.88 | 2.19 | 2.68 | 1.20-6.02 | 11.5 | 2.25 | 5.12 | 2.88-9.12 |
| Clinic-based | 28.1 | 6.07 | 4.63 | 3.20-6.70 | 30.3 | 4.98 | 6.09 | 4.27-8.70 |
| ≤ 2 BCs | 13.8 | 3.31 | 4.18 | 2.47-7.08 | 24.2 | 2.70 | 8.98 | 6.03-13.4 |
| ≥ 3 BCs | 20.1 | 4.95 | 4.07 | 2.63-6.30 | 17.6 | 4.52 | 3.90 | 2.44-6.21 |
Abbreviations: Obs, observed number of cases; Exp, expected number of cases; SIR, standardized incidence rate; CI, confidence interval; FDR, first-degree relative; BC, breast cancer.