Table 3.
Prevalence of disorders among Filipino newborns in a California, USA, Newborn Screening Laboratory, from 2005 to 2011a
| Conditions | Number of cases | Prevalence |
|---|---|---|
| Endocrinologic Disorders | ||
| Congenital adrenal hyperplasia (classical salt wasting) | 1 | 1:111,127 |
| Primary congenital hypothyroidism | 45 | 1: 2,469 |
| Transient hypothyroidism | 4 | 1: 27,782 |
| Variant hypothyroidism | 1 | 1:111,127 |
| Hemoglobinopathies | ||
| α-Thalassemia major | 5 | 1: 22,225 |
| β-Thalassemia major | 1 | 1: 111,127 |
| Hb E/Beta + thalassemia | 1 | 1: 111,127 |
| Hb H disease | 93 | 1: 1,195 |
| Hb H/constant spring disease | 2 | 1: 55,564 |
| Hb variant/beta + thalassemia | 1 | 1: 111,127 |
| Homozygous EE | 3 | 1: 37,042 |
| Sickle C disease (Hb S/C disease) | 2 | 1: 55,564 |
| Sickle cell anemia (Hb S/S disease) | 1 | 1:111,127 |
| Amino acid disorders | ||
| Phenylketonuria (PKU) | 4 | 1: 27,782 |
| Variant hyperphenylalaninemia | 1 | 1:111,127 |
| Maple syrup urine disease (MSUD) | 1 | 1:111,127 |
| Organic acid disorders | ||
| Methylmalonic acidemia (MMA) (mut 0) | 3 | 1: 37,042 |
| Methylmalonic acidemia (MMA) (mut –) | 2 | 1: 55,564 |
| β-Ketothiolase deficiency (BKT) | 1 | 1: 111,127 |
| Isobutyryl-CoA dehydrogenase deficiency (IBDHD) | 1 | 1:111,127 |
| Fatty acid oxidation disorders | ||
| Medium chain acyl-CoA dehydrogenase deficiency (MCAD deficiency) | 2 | 1:55,564 |
| Short chain acyl-CoA dehydrogenase deficiency (SCAD deficiency) | 3 | 1: 37,042 |
| Very long chain acyl-CoA dehydrogenase deficiency (VLCAD deficiency) | 3 | 1: 37,042 |
| Other fatty acid oxidation disorder | 2 | 1: 55,564 |
| Others | ||
| Partial BD deficiency | 1 | 1:111,127 |
| CFTR-related metabolic syndrome (CRMS) | 5 | 1:22,225 |
| Cystic fibrosis | 5 | 1: 22,225 |
| Classical galactosemia | 1 | 1: 111,127 |
| Duarte galactosemia (D/G) | 2 | 1: 55,564 |
| Other disorders | 2 | 1: 55,564 |
aTotal of 111,127 newborns screened