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. 2013 Apr 10;5(4):511–522. doi: 10.1002/wsbm.1224

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Copyright © 2013 Wiley Periodicals, Inc.

Re-use of this article is permitted in accordance with the Creative Commons Deed, Attribution 2.5, which does not permit commercial exploitation.

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Pathway analysis showing integration between signaling pathways, transcription factors, and adhesion genes. Wnt and BMP act at the top of the hierarchy to initiate the induction of EMT cascade. The transcriptional network, including Twist1/2, Zeb1/2, Snail1/2, Sox10, and Mitf, is active both in neural crest development and cancer. The transcription factors then interact with adhesion genes on the cell surface including N-cadherin (N-cad), E-cadherin (E-cad), Occludins (Ocln), Claudins (Cldn), and extracellular matrix proteins such as fibronectin (FN) and intermediate filament proteins such as vimentin (Vim). (The network was built with Ingenuity Pathway Analysis, Ingenuity Systems, Inc., Redwood City, CA and modified in Adobe Illustrator).