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. Author manuscript; available in PMC: 2014 Aug 1.
Published in final edited form as: Cancer Discov. 2013 May 6;3(8):894–907. doi: 10.1158/2159-8290.CD-13-0011

Figure 1.

Figure 1

Mammary tumor development in mice with tissue-specific ablation of Palb2. A, Schematic representation of the generation of the Palb2-floxed and knockout alleles. The full gene structure of Palb2 is shown on top. B, Kaplan-Meier survival curves of mice with mammary gland-specific deletion of Palb2, Trp53 or both genes. C, Diverse histology of Palb2-associated mouse mammary tumors. I-IV, the 4 different types of histology observed; V-VIII, enlarged views of the center regions of I-IV, respectively; IX, a solid tumor with a well-formed pushing margin; X, a solid tumor invading into fat tissue; XI-XII, higher power views of tumor cell nuclei and mitotic figures.