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. Author manuscript; available in PMC: 2014 Aug 1.
Published in final edited form as: Cancer Discov. 2013 May 6;3(8):894–907. doi: 10.1158/2159-8290.CD-13-0011

Figure 5.

Figure 5

Role of autophagy in Palb2-associated mammary tumor development. A, Kaplan-Meier survival curves showing mammary tumor development in Palb2-single and Palb2;Trp53-double conditional knockout mice in Becn1+/+ and Becn1+/− backgrounds. B, Autophagosomes observed in tumors from mice with indicated genotypes. Note that tumor #827 contains a Trp53 point mutation (Table 1), although it developed in Trp53-wild type mice. C, IHC analysis of autophagy substrate p62 in tumors arising from the 4 different genetic backgrounds as indicated. Tumors #751 and #163 still retained wild type Trp53, whereas #915 and #890 had acquired somatic mutations in Trp53 (Table 1). D, IHC analysis of cleaved caspase 3, a marker of apoptosis, in the same tumors as in C.