Table 1.
Clinical characteristics of patients with chronic Hepatitis C virus who developed thyroiditis (IIT cases) compared to patients with chronic Hepatitis C virus without evidence of thyroiditis (HCV controls)
| IIT Cases | HCV Controls | |
|---|---|---|
| Total (n = 245) | 53 | 192 |
| Gender (p < 0.006) | ||
| Male | 25 (47%) | 130 (68%) |
| Female | 28 (53%) | 62 (32%) |
| Ethnicity1 (p = NS) | ||
| Caucasian | 44 (83%) | 134 (70%) |
| Non-Caucasian/unknown | 9 (17%) | 58 (30%) |
| Average age at enrollment (yrs) | 52.4 | 53.7 |
| IIT diagnosis | N/A | |
| Hashimoto's thyroiditis | 18 (34%) | |
| Graves' disease | 4 (8%) | |
| Other inflammatory thyroiditis2 | 31 (58%) | |
| HCV/HIV co-infection | 6 (11%) | 55 (29%) |
| HCV genotype3 (p = NS) | ||
| Genotype 1 | 74% | 76% |
| Genotype 2 | 17.3% | 11.3% |
| Genotype 3 | 0 | 7.8% |
| Genotype 4 | 8.7% | 4.9% |
| No. of IFNα treatment responders3 | 50% | 39% |
1
Note that since a significant number of self-reported ethnicities were unknown, we used the PCA to confirm and match ethnicities between the IIT patients and the HCV controls (see text)
2
These include destructive thyroiditis and primary myxedema
3
Percentage based on available clinical information (HCV genotype: n = 23 (IIT cases), n = 141 (HCV controls); No. of IFNα treatment responders: n = 24 (IIT cases), n = 145 (HCV controls))