Table 2.
Haplotype analysis of putative IIT susceptibility genes: genes with multiple-associated SNPs that were found to be both associated with interferon-induced thyroiditis and upregulated by IFNα in PBMCs (see text).
| Gene | Chr | IIT Cases vs HCV Controls | IIT Cases vs Healthy Controls Gene (Caucasians) | ||
|---|---|---|---|---|---|
| Haplotypes | p-value | Haplotypes | p-value | ||
| SP100/110/140 | 2q37.1 | rs55796826-rs4972946-rs17330341-rs1972707 (1kb) | 6.4 × 10−5 | rs59559342-rs2033157-rs13007094-rs73106397 (1kb) | 2 × 10−4 |
| rs57841972-rs4972946-rs17330341-rs6743287-rs1972707 (1kb) | 1 × 10−4 | rs13007094-rs73106397-rs116469870 (2kb) | 7 × 10−4 | ||
| rs115474882-rs78723887-rs56317957-rs76029471 (1kb) | 3 × 10−4 | rs2114590-rs34855578-rs13395371-rs9989735-rs9989792 (1kb) | 1.6 × 10−3 | ||
| rs933957-rs6731421-rs12615773, rs56017039-rs6713654-rs2396744 (3kb) | 1.5 × 10−3 | rs3813464-rs4973304-rs10498245-rs10200874 (1kb) | 3.5 × 10−3 | ||
| HLA-A/B/C | 6p21.3 | HLA-C: rs9264921-rs364415 (<1kb) | 1.3 × 10−3 | HLA-A rs1611493-rs386014-rs9259852 (10kb) | 9 × 10−4 |
| HLA-B rs9501587-rs9266636-rs9266638, rs2244020-rs2507980 (<1kb) | 6.9 × 10−5 | ||||
| HLA-C rs12199223-rs3134745-rs3132486-rs3130696-rs9264731 (1kb) | 2.3 × 10−6 | ||||
| rs2596503-2596501 (<1kb); rs2523554-rs2596574-rs9266381-rs6457401 (3kb) | 4.4 × 10−4 | ||||
| TAP1 | 6p21.3 | rs2239701-rs2071465-rs4148870-rs2071552 (1kb) | 3.2 × 10−3 | rs6934645-rs12206377-rs260547 (3kb) | 5.9 × 10−5 |
| LILRA3 | 19q13.4 | rs75085835-rs117299550-rs7257187 (2kb) | 4.1 × 10−3 | rs36012517-rs73061042-rs11084333-rs73061043 (1kb) | 7 × 10−4 |
| INS | 11p15.5 | rs7114836-rs7126857-rs7127162(rs71472148)-rs10743180 (<1kb) | 1.3 × 10−3 | rs7126857-rs7127162 (rs71472148)-rs10743180-rs10840588 (<1kb) | 4.5 × 10−3 |