Table 3. Treatment-Related Toxicities by BMI (N=405).

Treatment Toxicity	All Patients (N=405)	Non-Obese (N = 115)	Obese (N = 290)	P-Value
Esophagitis				0.021
grade 0	152 (37.5%)	33 (28.7%)	119 (41%)
grade 2 or greater	253 (62.5%)	82 (71.3%)	171 (59%)
Nausea				0.177
grade 0	162 (40%)	52 (45.2%)	110 (37.9%)
grade 1 or greater	243 (60%)	63 (54.8%)	180 (62.1%)
Pneumonitis				0.519
grade 0	388 (95.8%)	109 (94.8%)	279 (96.2%)
grade 2 or greater	17 (4.2%)	6 (5.2%)	11 (3.8%)
Fistula Toxicity				0.284
grade 0	404 (99.8%)	114 (99.1%)	290 (100%)
grade 1 or greater	1 (0.2%)	1 (0.9%)
Stricture Toxicity				<0.001
grade 0	347 (85.7%)	83 (72.2%)	264 (91%)
grade 1 or greater	58 (14.3%)	32 (27.8%)	26 (9%)
Max Hematologic Toxicity				<0.001
grade 0	263 (66.1%)	61 (53%)	202 (71.4%)
grade 2 or greater	135 (33.9%)	54 (47%)	81 (28.6%)
Anemia				<0.001
grade 0	217 (54.5%)	43 (37.4%)	174 (61.5%)
grade 1 or greater	181 (45.5%)	72 (62.6%)	109 (38.5%)
Anemia Treatment Break or Dose Reduction				0.136
No	388 (97.5%)	110 (95.7%)	278 (98.2%)
Yes	10 (2.5%)	5 (4.3%)	5 (1.8%)
Leukopenia				0.064
grade 0	308 (77.4%)	82 (71.3%)	226 (79.9%)
grade 2 or greater	90 (22.6%)	33 (28.7%)	57 (20.1%)
WBC Treatment Break or Dose Reduction				0.039
No	375 (94.2%)	104 (90.4%)	271 (95.8%)
Yes	23 (5.8%)	11 (9.6%)	12 (4.2%)
Neutropenia				0.01
grade 0	317 (80.3%)	83 (72.2%)	234 (83.6%)
grade 1 or greater	78 (19.7%)	32 (27.8%)	46 (16.4%)
ANC Treatment Break or Dose Reduction				0.005
No	374 (94%)	102 (88.7%)	272 (96.1%)
Yes	24 (6%)	13 (11.3%)	11 (3.9%)
Thrombocytopenia				0.02
grade 0	220 (55.3%)	74 (64.3%)	146 (51.6%)
grade 1 or greater	178 (44.7%)	41 (35.7%)	137 (48.4%)
Platelet Break or Dose Reduction				0.035
No	371 (93.2%)	112 (97.4%)	259 (91.5%)
Yes	27 (6.8%)	3 (2.6%)	24 (8.5%)