Table 1.
DA | cocaine | GBR12909 | |
---|---|---|---|
IC50 (nM) | |||
WT hDAT | 895 ± 80 | 370 ± 40 | 160 ± 30 |
Y470H-hDAT | 737 ± 72 | 100 ± 30* | 50 ± 10* |
Data are calculated as a percentage of DA uptake in the absence of substrate or inhibitor and analyzed by nonlinear regression. Data are presented as mean ± S.E.M. of IC50 values from three to four independent experiments performed in duplicate.
p < 0.05 compared with WT hDAT (unpaired Student's t test).