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. Author manuscript; available in PMC: 2014 Sep 1.
Published in final edited form as: J Neuroimmune Pharmacol. 2013 May 5;8(4):975–987. doi: 10.1007/s11481-013-9464-6

Table 1.

Summary of inhibitory activities in [3H]DA uptake in WT and mutated hDAT in the presence of DA, cocaine or GBR12909

DA cocaine GBR12909
IC50 (nM)
WT hDAT 895 ± 80 370 ± 40 160 ± 30
Y470H-hDAT 737 ± 72 100 ± 30* 50 ± 10*

Data are calculated as a percentage of DA uptake in the absence of substrate or inhibitor and analyzed by nonlinear regression. Data are presented as mean ± S.E.M. of IC50 values from three to four independent experiments performed in duplicate.

*

p < 0.05 compared with WT hDAT (unpaired Student's t test).