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. Author manuscript; available in PMC: 2015 Jan 25.
Published in final edited form as: Mol Cell Endocrinol. 2013 Apr 4;382(1):10.1016/j.mce.2013.03.016. doi: 10.1016/j.mce.2013.03.016

Fig. 1. Expression of exogenous Cyclin D1 in the mammary epithelium of Cyclin D1 knockout mice does not accelerate ErbB2-induced mammary tumorigenesis.

Fig. 1

Immunostaining of Cyclin D1 in histologic sections of normal and hyperplastic mammary ducts as well as mammary tumors of MMTV-neu MMTV-tTA TetO-Cyclin D1 triple transgenic females (A, B), MMTV-neu MMTV-tTA TetO-Cyclin D1 Cyclin D1−/− mice (C-E), and MMTV-neu Cyclin D1−/− littermate controls (F). Slides were counterstained with hematoxylin; bar represent 50 μm. Inset in panel C shows a section of the salivary gland, which is serves as a positive control for expression of MMTV-driven transgenes (here MMTV-tTA mediated transactivation of TetO-Cyclin D1).