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. Author manuscript; available in PMC: 2013 Aug 10.
Published in final edited form as: Circ Res. 2007 Mar 22;100(8):1200–1207. doi: 10.1161/01.RES.0000264499.48737.69

Figure 4.

Figure 4

Functional evaluation of HDL from PON3 Tg and non-Tg mice. A, The ability of HDL to prevent LDL oxidation. Human LDL was incubated in the presence or absence of HDL isolated from non-Tg and PON3 Tg-1 mice in the presence of 5 µmol/L CuSO4 for 3 hours at 37°C to induce oxidation. At the end of incubation, the amount of lipid hydroperoxides (LOOH) in each sample was measured. The data shown are mean and SE. *P<0.01 vs LDL; **P<0.001 vs LDL. B, The ability of HDL to mediate cholesterol efflux from macrophage. Cholesterol-loaded macrophages were incubated with media alone or various HDL for 4 hours, as described under Materials and Methods. The data shown are mean and SE. ***P<0.0001 vs media.