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. Author manuscript; available in PMC: 2013 Aug 11.
Published in final edited form as: Cell Rep. 2013 Jul 11;4(2):287–301. doi: 10.1016/j.celrep.2013.06.019

Figure 4. Sympathetic de-innervation in mature animals does not affect islet architecture and glucose tolerance.

Figure 4

(A–C) Normal islet morphology and glucose tolerance with 6-OHDA administration at a late postnatal stage (postnatal day 21). P21-old mice were serially injected with 6-OHDA or vehicle for 7 days, and then analyzed at 1.5 months of age. TH-positive sympathetic fibers (arrows in A) are sparser in mature animals, and are completely lost with 6-OHDA administration (B). n=6 mice for each treatment; t test, mean ± SEM.