Table 2. Values used for each parameter in the model.
The values shown here were used to generate the E(C(t)) curves used for the final simulation testing.
| Name | Description | Values used in the simulated data | Units |
|---|---|---|---|
| K | Number of drug doses | 4 | (None) |
| Dk | Magnitudes of each drug dose | Not simulated; equal doses, with the first dose producing a plasma concentration peak = 1 | arbitrary (e.g., ng) |
| t | Time | from 0 to 40 | min |
| tk | Time of drug dose k | 8, 16, 24, and 32 | min |
| ts | Fixed time delay (shift) | 0.43 | min |
| t½ | Elimination half-life for loss of drug from plasma | 41 | min |
| Emax | Maximal possible (asymptotic) effect of drug | 10 | Arbitrary imaging units (e.g., scaled MRI signal intensity) |
| EC50 | Concentration producing 50% of the maximal possible effect, Emax/2 (when Hill coefficient n = 1) | One of the following values for each data set: 0.1, 0.43, 1.0, 1.7, 3.0, 3.8, 5.0, 6.1, 8.0, 9.2 | Arbitrary plasma concentration units (e.g., ng/mL) |
| n | Hill coefficient | 1 | (none) |
| M | Degree of noise polynomial polyM(t) | 1 | (none) |
| ak | Coefficients of polyM(t) | 1000, 0.05; i.e., y = 1000 + 0.05t |
a0: arbitrary imaging units (e.g., scaled MRI signal intensity) a1: (imaging units) ⋅ min−1 ak: (imaging units) ⋅ min−k |