TABLE 3.
Tempo of skin graft rejection in comparison with SLAd IgG production
| Animal | SLAd lgG postinjection 1 (d) | SLAd lgG postinjection 2 (d) | SLAd lgG postskin graft (d) | Time course of skin graft rejection (start/completion) | Rejection according to pathology (d) |
|---|---|---|---|---|---|
| 17476 | None | N/A | 10 | 4/8 | 7 |
| 17506 | None | N/A | 10 | 4/8 | 7 |
| 17471 | None | 5 | N/A | 1/7 | N/A* |
| 17475 | None | 7 | N/A | 1/7 | 4 |
| 17164 | None | 1 | N/A | 1/7 | 4 |
| 17165 | None | 5 | N/A | 2/7 | 4 |
| 17162 | None | 2 | N/A | 1/7 | 4 |
| 17163 | None | 5 | N/A | 1/7 | 4 |
| 17307 | None | 10 | N/A | 2/7 | 4 |
| 17308 | None | 7 | N/A | 1/7 | 4 |
| 17375 | None | None | 10 | 4/8 | 7 |
| 17377 | None | None | 10 | 4/8 | 7 |
In vitro assessment of SLAd IgG production after second pUTC injection is compared with the tempo of skin graft rejection in vivo (start-to-completion of rejection d 1–7). A technical error occurred with skin grafting of animal 17471, so that day 4 pathologic observation of the graft was impossible (*). Because day 7 rejection was identical to animal 17475 with IgG production after second injection was identical and with visual criteria analysis of the graft demonstrating accelerated rejection, it is likely that this animal would have demonstrated an accelerated course of rejection by histology.
SLA, swine leukocyte antigen; N/A, not applicable or available.