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. Author manuscript; available in PMC: 2014 Feb 8.
Published in final edited form as: Nature. 2013 Aug 8;500(7461):207–211. doi: 10.1038/nature12064

Figure 2. HeLa HPV integration locus.

Figure 2

a. Chromosome 8 read depth flanking the HPV integration site (top, blue line), windowed copy-number ratios (purple points) and integer copy states (red bars, middle), and corresponding segments and breakpoints (circled numbers with genomic coordinates, bottom). b. Proposed HPV integration structure: per-segment copy number (upper left), non-rearranged haplotype B (CN=1, upper right), rearranged haplotype A with HPV insertion (CN=3, bottom) carrying ~3 and ~6 tandem copies of repeats ‘R1’ and ‘R2’ respectively. c. The partial HPV-18 genome and corresponding genes (gray and blue, top) with breakpoints highlighted by numbered circles. For reference, the entire HPV-18 genome is shown (bottom).