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. Author manuscript; available in PMC: 2014 Feb 8.
Published in final edited form as: Nature. 2013 Aug 8;500(7461):207–211. doi: 10.1038/nature12064

Figure 4. Haplotype-specific regulation near the HPV integration site.

Figure 4

a. Long-range chromatin interactions between the HPV and MYC loci demonstrated by ChIA-PET28 with the RNA polymerase II signal (top) shown for HeLa S3 and an HPV− cell line (K562). Chromatin interactions (below) are highlighted with a green arrow. Bar graphs show read counts at phased, informative sites in MYC (red = A, blue = B). b. Transcript abundance in HeLa S3 across the MYC locus measured by RNA-Seq. Overall coverage is shown in gray (top) with phased, informative sites highlighted (green ticks; italic indicates non-reference allele). Haplotype contributions at each variant are shown at bottom, as in a.