Table 5.
Genotype-phenotype correlation between Claudin-2 marker (rs12014762) polymorphism and clinical characteristics of 677 patients with Crohn’s disease (all families)
| rs12014762 Crohn’s disease | At least one C | T | P value |
| Sex | |||
| Male | 265 | 47 | |
| Female | 354 | 11 | |
| Age at diagnosis (yr) | |||
| Mean (SD) | 24.48 (12.11) | 24.36 (11.46) | 0.90 |
| Median (range) | 22 (3-70) | 22 (8-63) | |
| Location at onset: | n = 583 | n = 54 | |
| Pure colonic disease | 78 | 6 | 0.64 |
| Pure ileal disease | 117 | 14 | 0.31 |
| Ileocolonic disease | 274 | 309 | 0.87 |
| Any colonic disease | 414 | 37 | 0.70 |
| Any ileal disease | 424 | 42 | 0.42 |
| Upper digestive tract | 118 | 12 | 0.73 |
| Perineal disease | 147 | 11 | 0.53 |
| Granuloma | 237/478 | 26/43 | 0.12 |
| Penetrating disease | 218/478 | 22/43 | 0.48 |
| Strictures | 221/478 | 15/43 | 0.15 |
| Extra-digestive symptoms | 190/619 | 15/58 | 0.44 |
| Smoking habits | n = 505 | n = 51 | |
| Non-smoker | 272 | 21 | 0.08 |
| Smoker | 157 | 21 | 0.14 |
| Ex-smoker | 76 | 9 | 0.62 |