Table 4.

Predictors of completion times. Table shows mean difference in calendar days related to variable. A negative value represents a reduction in the mean number of days to FE in comparison to the mean number of days for all contracts. Univariate analysis shows the duration of the process step(s) if the variant was present or absent. The Student's t‐test (p value) was used as a test for significance

Predictors of full execution times
		Univariate analysis		Multivariable analysis
Milestone/variable	Present (days)	Absent (days)	p <	Mean days difference	p <
Final negotiation
Master agreement	34	62	< 0.0000	−33	0
Previously negotiated terms	46	57	0.034	−22	0.001
Multicenter clinical trial	54	58	0.271	6	0.389
CRO	59	53	0.865	6	0.255
Investigator initiated	70	53	0.989	15	0.088
Full execution
Master agreement	99	104	0.23	−10	0.165
Previously negotiated terms	88	106	0.009	−22	0.007
Multicenter clinical trial	103	100	0.728	8	0.401
CRO	115	99	0.992	16	0.019
Investigator initiated	107	103	0.682	9	0.437
IRB approval
Master agreement	67	64	0.684	2	0.764
Previously negotiated terms	61	66	0.237	−5	0.474
Multicenter clinical trial	67	56	0.946	11	0.154
CRO	N/A	N/A	N/A	11	0.057
Investigator initiated	62	65	0.363	6	0.514
Contract and IRB approval
Master agreement	126	142	< 0.062	−16	0.139
Previously negotiated terms	128	140	0.137	−16	0.182
Multicenter clinical trial	135	148	0.134	0	0.995
CRO	154	131	0.986	27	0.011
Investigator initiated	169	133	0.993	36	0.033