Table 2.

Periosteal and Endocortical Dynamic Histomorphometric Measurements Performed on 12- and 20-Week-Old APKO Mice and Sex- and Age-Matched WT Mice at the Femoral Midshaft

Mice	Periosteum			Endosteum
	MS/BS (%)	MAR (μm/d)	BFR/BS (μm3/μm2·d)	MS/BS (%)	MAR (μm/d)	BFR/BS (μm3/μm2·d)
Male
12 weeks, WT	32.5 ± 10.8	1.57 ± 0.14	0.50 ± 0.14	43.4 ± 17.3	1.37 ± 0.29	0.56 ± 0.08
12 weeks, APKO	50.9 ± 19.7	2.48 ± 0.78a	1.21 ± 0.49a	30.9 ± 13.2	0.97 ± 0.69	0.35 ± 0.31
20 weeks, WT	13.5 ± 9.8	1.03 ± 0.11	0.14 ± 0.10	42.3 ± 5.0	0.69 ± 0.27	0.30 ± 0.15
20 weeks, APKO	32.7 ± 13.4a	1.97 ± 0.29a	0.67 ± 0.37a	36.5 ± 13.3	0.65 ± 0.43	0.27 ± 0.19
Female
12 weeks, WT	33.0 ± 15.8	2.12 ± 0.77	0.70 ± 0.37	16.9 ± 19.6	0.96 ± 1.25	0.32 ± 0.53
12 weeks, APKO	43.7 ± 9.3	1.53 ± 0.44	0.68 ± 0.30	25.0 ± 17.3	1.86 ± 1.23	0.36 ± 0.32
20 weeks, WT	21.6 ± 7.1	1.29 ± 0.44	0.30 ± 0.15	34.8 ± 9.5	0.60 ± 0.55	0.36 ± 0.15
20 weeks, APKO	44.2 ± 17.4	1.26 ± 0.34	0.56 ± 0.23	40.9 ± 11.6	1.06 ± 0.49	0.41 ± 0.32

The values are the mean ± SD (n = 3–4 per group).

^aStatistically significant changes relative to age- and sex-matched controls, P < 0.05.