Table 2.
Mice | Periosteum |
Endosteum |
||||
---|---|---|---|---|---|---|
MS/BS (%) | MAR (μm/d) | BFR/BS (μm3/μm2·d) | MS/BS (%) | MAR (μm/d) | BFR/BS (μm3/μm2·d) | |
Male | ||||||
12 weeks, WT | 32.5 ± 10.8 | 1.57 ± 0.14 | 0.50 ± 0.14 | 43.4 ± 17.3 | 1.37 ± 0.29 | 0.56 ± 0.08 |
12 weeks, APKO | 50.9 ± 19.7 | 2.48 ± 0.78a | 1.21 ± 0.49a | 30.9 ± 13.2 | 0.97 ± 0.69 | 0.35 ± 0.31 |
20 weeks, WT | 13.5 ± 9.8 | 1.03 ± 0.11 | 0.14 ± 0.10 | 42.3 ± 5.0 | 0.69 ± 0.27 | 0.30 ± 0.15 |
20 weeks, APKO | 32.7 ± 13.4a | 1.97 ± 0.29a | 0.67 ± 0.37a | 36.5 ± 13.3 | 0.65 ± 0.43 | 0.27 ± 0.19 |
Female | ||||||
12 weeks, WT | 33.0 ± 15.8 | 2.12 ± 0.77 | 0.70 ± 0.37 | 16.9 ± 19.6 | 0.96 ± 1.25 | 0.32 ± 0.53 |
12 weeks, APKO | 43.7 ± 9.3 | 1.53 ± 0.44 | 0.68 ± 0.30 | 25.0 ± 17.3 | 1.86 ± 1.23 | 0.36 ± 0.32 |
20 weeks, WT | 21.6 ± 7.1 | 1.29 ± 0.44 | 0.30 ± 0.15 | 34.8 ± 9.5 | 0.60 ± 0.55 | 0.36 ± 0.15 |
20 weeks, APKO | 44.2 ± 17.4 | 1.26 ± 0.34 | 0.56 ± 0.23 | 40.9 ± 11.6 | 1.06 ± 0.49 | 0.41 ± 0.32 |
The values are the mean ± SD (n = 3–4 per group).
Statistically significant changes relative to age- and sex-matched controls, P < 0.05.