Table 3.
Cancellous Dynamic Histomorphometric Measurements Performed on 12- and 20-Week-Old APKO Mice and Age- and Sex-Matched Controls at the Distal Femur
| Mice | MS/BS (%) | MAR (μm/d) | BFR/BS (μm3/μm2·d) |
|---|---|---|---|
| Male | |||
| 12 weeks, WT | 38.9 ± 6.4 | 1.37 ± 0.07 | 0.53 ± 0.11 |
| 12 weeks, APKO | 51.2 ± 15.8 | 2.08 ± 0.19a | 1.05 ± 0.40a |
| 20 weeks, WT | 33.7 ± 5.7 | 1.49 ± 0.34 | 0.49 ± 0.14 |
| 20 weeks, APKO | 41.9 ± 4.9 | 1.90 ± 0.01 | 0.79 ± 0.09a |
| Female | |||
| 12 weeks, WT | 46.2 ± 7.0 | 2.16 ± 0.36 | 0.90 ± 0.08 |
| 12 weeks, APKO | 46.5 ± 15.8 | 2.60 ± 0.19 | 1.19 ± 0.40 |
| 20 weeks, WT | 32.1 ± 2.3 | 2.47 ± 0.28 | 0.79 ± 0.09 |
| 20 weeks, APKO | 44.8 ± 4.2a | 2.14 ± 0.36 | 0.95 ± 0.13a |
The values are the mean ± SD (n = 3–5 per group).
a
Statistically significant changes relative to age- and sex-matched controls, P < 0.05.