Table 3.
Antiparasitic activities on Plasmodium falciparum FcB1 and Trypanosoma brucei gambiense (IC50, µg/mL).a
| Compounds: | 4 | 9 | 10 | 11 | 17 | 18 | 19 | 23 | 24 | 25 |
| P. falciparum FcB1 | 0.04 ± 0.02 | 0.07 ± 0.02 | 0.55 ± 0.16 | 2.30 ± 1.40 | 0.51 ± 0.18 | 0.20 ± 0.04 | 0.42 ± 0.09 | 7.70 ± 2.50 | 1.10 | 2.70 ± 1.30 |
| T. brucei gambiense | 0.4 | 1.5 | 5.8 | >10 | 0.8 | 1.6 | >10 | >10 | 1.7 | >10 |
aFor P. falciparum FcB1, all tests performed in triplicate (except compound 24); values were calculated by sigmoidal curve fitting and are displayed as mean ±SD.