Table 2.
Distribution of genotypes and allele frequencies of FcγRIIb 187-Ile/Thr polymorphism in anti-CCP positive (anti-CCP+) and negative (anti-CCP−) Taiwanese RA patients
| Anti-CCP− (n = 131) | Anti-CCP+ (n = 464) | χ2 | P | OR | 95% CI | |
|---|---|---|---|---|---|---|
| Genotype frequency, no. (%) | ||||||
| 187-I/I | 66 (50.4) | 301 (64.9) | 9.820 | 0.007 | ||
| 187-I/T | 54 (41.2) | 142 (30.6) | ||||
| 187-T/T | 11 (8.4) | 21 (4.5) | ||||
| 187-I/I | 66 (50.4) | 301 (64.9)a | 9.074 | 0.003 | 1.819b | 1.229–2.691 |
| 187-I/T+187-T/T | 65 (49.6) | 163 (35.1) | ||||
| Allele frequency, no. (%) | ||||||
| 187-I allele | 186 (71.0) | 744 (80.2)a | 10.084 | 0.001 | 1.652 | 1.210–2.257 |
| 187-T allele | 76 (29.0) | 184 (19.8) |
The χ2 test was used to calculate the P-values. The odds ratio (OR) and 95% confidence interval (95% CI) were calculated by comparing the genotype and allele frequency differences between anti-CCP positive patients and anti-CCP negative patients.
Significant enrichment of 187-Ile homozygotes was observed in anti-CCP+ RA patients as compared with normal controls (χ2 = 7.920,P=0.005; odds ratio 1.438 (95% CI 1.116–1.852)) and a significant enrichment of 187-Ile allele was also observed in anti-CCP+ RA patients as compared with normal controls ( χ2 = 7.760, P = 0.005; odds ratio 1.348 (95% CI 1.092–1.664)).
Multiple variable logistic regression analysis was also performed by adjusting for age, sex, autoantibody production and severity phenotypes (P = 0.007, odds ratio 1.876 (95% CI 1.187–2.965))