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. Author manuscript; available in PMC: 2013 Nov 21.
Published in final edited form as: J Am Chem Soc. 2012 Nov 8;134(46):19223–19233. doi: 10.1021/ja3090687

Figure 2.

Figure 2

Inhibitory effects of [Rh(chrysi)(phen)(DPE)]3+as a function of incubation time on cellular proliferation. Shown are plots of BrdU incorporation (a measure of DNA synthesis and therefore cellular proliferation) normalized to the BrdU incorporation of untreated cells as a function of rhodium concentration. Standard error bars for five trials are shown. MMR-proficient HCT116N cells (green) and MMR-deficient HCT116O cells (red) were plated and allowed 24 h to adhere before incubation with 0–5 μM for 1, 3, 6, 12, or 24 h. At the end of the incubations, the medium containing rhodium was replaced with fresh medium for the remainder of the 72 h period, followed by ELISA analysis. BrdU was added to the medium 24 h prior to analysis. 1 and 3 h plots are not shown, as no activity was observed.