Table 4.

Results of the Within-Group Functional Connectivity Analysis: Significant Clusters of Functional Correlations with the Three Seeds Within the Control (n = 19) and Schizophrenia (n = 18) Groups

Seed	Control Region	BA	k	Tal (x,y,z)	Z Score	Schizophrenia Region	BA	k	Tal (x,y,z)	Z Score
L m/pCC	L anterior cingulate gyrus	32	2581	−6,41,2	5.35	R anterior cingulate gyrus	32	2565	10,32,−6	5.13
	L mid/posterior cingulate gyrus	23	678	−1, −34,24	Inf	L mid/posterior cingulate gyrus	23	682	−4, −34, 24	7.54
R m/pCC	L anterior cingulate gyrus	24/32	2065	−4, 26, 24	5.95	L anterior cingulate gyrus	32	2101	−6, 34, 0	5.63
	R posterior cingulate gyrus/RSC	23/29	453	3, −42, 20	5.35	L posterior cingulate gyrus	23	47	−8, −36, 24	3.67
RmPFC	R anterior cingulate and medial orbitofrontal gyri	32/11	3150	10,28, −15	7.44	L medial orbitofrontal gyrus	11/10	2818	−6,39,−18	6.77
	L posterior cingulate gyrus/RSC	23/30	274	−10,−52,23	3.90	L posterior cingulate gyrus/RSC	23/30	264	−1, −50, 18	3.84

Location (BA and name of region) and size (k) of clusters within the midline cortical search area that showed significant connectivity with each of the three seeds for the control subjects (n = 18) and the patients with schizophrenia (n = 18). Talairach (Tal) coordinates and Z scores of the peak voxel within each cluster are also included. The three seed regions-of-interest were each constructed by creating an 8 mm sphere around the voxel showing the peak between-group difference in the cortical surface, task-based functional magnetic resonance imaging analysis (see Methods and Materials). Talairach coordinates (x,y,z) of the center of each seed: 8, 42, −15 (right mPFC); −5, −30, 34 (left m/pCC); 6, −22, 32 (right m/pCC).

BA, Brodmann's area; L, left; mPFC, right medial prefrontal cortex; m/pCC, middle and dorsal-posterior cingulate cortex; R, right; RSC, retrosplenial cortex.