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. Author manuscript; available in PMC: 2013 Aug 12.
Published in final edited form as: Adv Pharmacol. 2012;64:303–325. doi: 10.1016/B978-0-12-394816-8.00009-X

FIGURE 1. Domain structure of STEP isoforms.

FIGURE 1

STEP occurs as two major isoforms: STEP61 (541 amino acid residues) and STEP46 (369 amino acid residues). Both these isoforms have conserved PTP catalytic domain at C-terminal and KIM (kinase interacting motif) domain. KIM domain has a conserved serine residue, which gets phosphorylated by protein kinase A (PKA), denoted as Ser221 in STEP61 and Ser49 in STEP46. STEP61 isoform has additional N-terminal region (172 amino acids) containing polyproline-rich domains (PP) and transmembrane domains (TM).