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. 2013 Jul 26;9:1501–1507. doi: 10.3762/bjoc.9.171

Table 2.

Investigation of 3-substituted indazoles.a

graphic file with name Beilstein_J_Org_Chem-09-1501-i003.jpg
Cpd R CaCi-2
IC50 (µM)b 		CaCi-8
IC50 (µM)b
21 -H inactive inactive
22 -Et inactive inactive
23 graphic file with name Beilstein_J_Org_Chem-09-1501-i004.jpg inactive inactive
24 graphic file with name Beilstein_J_Org_Chem-09-1501-i005.jpg inactive inactive
25 graphic file with name Beilstein_J_Org_Chem-09-1501-i006.jpg 2.3 ± 0.3 6.0 ± 1.7
26 graphic file with name Beilstein_J_Org_Chem-09-1501-i007.jpg inactive inactive
27 graphic file with name Beilstein_J_Org_Chem-09-1501-i008.jpg inactive 21.1 ± 3.3
28 graphic file with name Beilstein_J_Org_Chem-09-1501-i009.jpg inactive inactive
29 graphic file with name Beilstein_J_Org_Chem-09-1501-i010.jpg 12.9 ± 1.7 inactive

aCaCi-2 and CaCi-8 cells were incubated at 37 °C for 48 hours with test compound and 8 µg/mL (26 µM) fluconazole. bAverage of at least three independent experiments, performed in duplicate. Inactive compounds displayed negligible activity at concentrations below 26 µM.