Table 1. Effects of genetic mutations within effector pathways on diabetes in NOD mice.

Legend: Bid – BH3-interacting domain death agonist, CTL – cytotoxic T lymphocyte, dnFADD – dominant-negative Fas-associated death domain, Fascg – dominant-negative form of Fas. IFNγ – interferon gamma, IFNγR1/2 – interferon gamma receptor 1/2, MHC – major histocompatibility complex, NOD – nonobese diabetic, NODlpr – CD95-deficient variant (lpr) of the NOD mouse, RIP – rat insulin promoter, TNF – tumor necrosis factor, TNFR1 – tumor necrosis factor receptor 1.