Table 2.
Studies comparing RFA and surgical resection for HCC: randomized or cohort studies with and without propensity score matching
| Authors (year) | Study design | Treatment method | No. of patients | Max size (cm)/ No. of tumor (s) | Overall Survival Rate (%) |
p value | |||
|---|---|---|---|---|---|---|---|---|---|
| 1-year | 2-year | 3-year | 5-year | ||||||
| Vivarelli et al. (2004) (65) | Cohort | RFA | C-P A: 43 | NA | 82 | NA | 43 | NA | 0.02 |
| HR | C-P A: 70 | NA | 88 | NA | 71 | NA | |||
| RFA | C-P B: 36 | NA | 74 | NA | 25 | NA | NS | ||
| HR | C-P B: 9 | NA | 52 | NA | 19 | NA | |||
| Chen et al. (2006) (16) | RCT | RFAa | C-P A: 71 | 5/1 | 95.8 | 82.1 | 71.4 | 67.9b | NS |
| HR | C-P A: 90 | 5/1 | 93.3 | 82.3 | 73.4 | 64.0b | |||
| Hung et al. (2011) (17) | Propensity | RFA | 66 | 2/1 | 98.3 | 94.9 | 86.4 | 77.8 | NS |
| HR | 50 | 2/1 | 100 | 95.9 | 91.1 | 84.6 | |||
| Wang et al. (2012) (18) | Cohort | RFA | 91 | 96.7 | NA | 80.3 | 72 | 0.073 | |
| 2/1 | |||||||||
| HR | 52 | 98 | NA | 98 | 91.5 | ||||
| Wang et al. (2012) (18) | RFA | 254 | 91.6 | NA | 73.5 | 57.4 | 0.001 | ||
| 3/3, 5/1 | |||||||||
| HR | 208 | 96.1 | NA | 87.8 | 71.2 | ||||
| Feng et al. (2012) (66) | RCT | RFA | 84 | 93.1 | 83.1 | 67.2 | NA | 0.342 | |
| 4/2 | |||||||||
| HR | 84 | 96 | 87.6 | 74.8 | NA | ||||
a
Additional treatment with ethanol injection or chemoembolization
b
Four-year survival rate; HR=hepatic resection; RCT=randomized cotrol trial; NS=not significant.