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. Author manuscript; available in PMC: 2014 Jul 1.
Published in final edited form as: Eur J Med Chem. 2013 Apr 28;65:60–69. doi: 10.1016/j.ejmech.2013.04.038

Fig. 2.

Fig. 2

Inhibition of HER2-HER3 interaction evaluated by PLA assay (Duolink II). A) SKBR-3 cells without any treatment. Red dots indicate heterodimerization of HER2-HER3 proteins. Notice the overexpression and dimerization of HER2 with HER3. B) SKBR-3 cells treated with a control peptide. Notice that HER2-HER3 dimerization is not inhibited. C) and D), 0.5 μM and 0.8 μM compound 5-1 treated SKBR-3 cells. Compound 5-1 inhibited HER2-HER3 dimerization indicated by the significant reduction in the number of red dots.