Table 1.

Biochemical Evidence of Methemoglobinemia and Intravascular Hemolysis after Rasburicase Administration.^*

Variable	Reference Range	Rasburicase Administration
		Before	6–18 Hr After	48–96 Hr After
Uric acid (mg/dl)	3.7–8.6	9.0	2.2	3.3
Hemoglobin (g/dl)	13.7–17.5	13.1	10.7	4.5
Methemoglobin (%)	0.0–1.9		12.2	6.9
Oxyhemoglobin (%)	94–97		86
Haptoglobin (mg/dl)	30–200		130	10
Lactate dehydrogenase (U/liter)	113–226	158	1166	1229
Bilirubin, indirect (mg/dl)	0.1–0.8	0.3	0.3	3.0
Plasma oxyhemoglobin (mg/dl)	0.0–12.4			30.9
Tricuspid regurgitant jet velocity (m/sec)	1.7–2.8	2.9		3.5

^*To convert the values for uric acid to millimoles per liter, multiply by 0.059. To convert the values for plasma oxyhemoglobin to micromoles per liter, multiply by 0.155. To convert the values for bilirubin to micromoles per liter, multiply by 17.1.