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Published in final edited form as: Nat Genet. 2010 Mar 7;42(4):289–291. doi: 10.1038/ng.547

Regional plot of the 5q22 locus and follow-up expression studies. (a) Regional plot showing the associated SNPs in the TSLP-WDR36 region. The relative position of each SNP is plotted against −log10 P values and the recombination rate in the region. (b,c) TSLP mRNA is increased in the esophagus in EoE cases. Quantitative PCR on esophageal biopsies from 26 unaffected individuals (NL) and 33 EoE cases show that mRNA levels of TSLP are significantly increased in EoE (c), but that WDR36 (b) is not. Data are normalized to GAPDH mRNA levels. ***, P < 0.0001; ns, not significant. (d) TSLP expression level stratified by rs3806932 genotype. TSLP expression is decreased in individuals homozygous for the protective minor allele (G). Error bars in b–d, interquartile range.

Regional plot of the 5q22 locus and follow-up expression studies. (a) Regional plot showing the associated SNPs in the TSLP-WDR36 region. The relative position of each SNP is plotted against −log10 P values and the recombination rate in the region. (b,c) TSLP mRNA is increased in the esophagus in EoE cases. Quantitative PCR on esophageal biopsies from 26 unaffected individuals (NL) and 33 EoE cases show that mRNA levels of TSLP are significantly increased in EoE (c), but that WDR36 (b) is not. Data are normalized to GAPDH mRNA levels. ***, P < 0.0001; ns, not significant. (d) TSLP expression level stratified by rs3806932 genotype. TSLP expression is decreased in individuals homozygous for the protective minor allele (G). Error bars in b–d, interquartile range.