Table.

MicroRNA involved in lipid and glucose

Regulator	Tissue/Cell Type	Target genes	Function	Reference
Let-7	Mouse adipose and skeletal muscle	INSR, IGF1R, IR2, TSC1, RICTOR	↑Insulin Sensitivity,↑ Glucose metabolism	54,55
	3T3-L1 cells	HMGA2	↓Adipogenesis, Adipose differentiation	20
miR-9	NS-1E cells, Mouse pancreatic β islets	OCT, SIRT1	↓Insulin secretion	49,50
miR-24	Mouse pancreatic β cells	SOX6, BHLHE22	↑Insulin biosynthesis	44
miR-26	Mouse pancreatic β cells	SOX6, BHLHE23	↑Insulin biosynthesis	45
miR-27	3T3-L1 cels	PPARG, ANGTPL3, GPAM	↓Adipogenesis, Adipose differentiation	13,14
miR-29	MIN6 cells, Mouse pancreatic β islets 3T3-L1 cels	MCT1 ?	↓Insulin secretion	52 58
miR-33a/b	Huh-7, HepG2, Mouse liver	ABCA1, ABCG1, ABCB11, ATP8B1	↓ Cholesterol Transport/Export	15, 16, 19, 33
	Huh-7, HepG2, Mouse liver	NPC1, CROT, CPT1A, HADHB, AMPKα1	↓ β-Oxidation	10,19,6
	Huh-7, HepG2, Mouse liver	IRS2, SIRT6	↓Insulin signaling	6
	MIN6 cells, Mouse and human pancreatic β islets	ABCA1	↓Insulin secretion	51
miR-34a	HepG2, Mouse liver	SIRT1	↑Insulin secretion	37
miR-96	INS-1E cells, MIN6 cells	Granuphilin	↓Insulin secretion	48
miR-103/107	3T3-L1 cels, Mouse Liver	CAV-1	↓Adipose differentiation, ↓Insulin sensitivity	59
miR-122	Mouse liver	HMGCR	↑Cholesterol Synthesis	22
	HepG2	ALDO, G6PC	Glucose homeostasis	7
		AMPKα1	↑ β-Oxidation	7
miR-124	MIN6 cells	RAB27A	↓Insulin secretion	48
miR-143	Human adipocytes	ERK5	↑Adipose differentiation	8
miR-148	MI N6 cells	SOX6, BHLHE22	↑Insulin biosynthesis	44
miR-182	MI N6 cells	SOX6, BHLHE23	↑Insulin biosynthesis	45
miR-208	Mouse heart	MED13	↑Insulin sensitivity, ↑glucose tolerance	60
miR-370	HepG2	CPT1A	↓ β-Oxidation	11
miR-375	Mouse pancreas	PDK, MTPN	Pancreas homeostasis	46
miR-378/378*	3T3-L1 cels	FABP4, FASN, SCD1	↑Adipose differentiation	9