FIG. 6.

The figure presents data corresponding to that in Figure 3, only here the kinetic analysis is performed with the extended model to return estimates of K^trans, v_e, and v_p. Panels (a) and (b) demonstrate K^trans values for scans 1 and 2, respectively. Panels (c) and (d) demonstrate cCorresponding v_e values for scans 1 and 2, respectively, whereas panels (e) and (f) show corresponding v_p values for scans 1 and 2, respectively. As was the case in the Figs. 3 and 4, voxels with parameter values outside of the acceptable range for K^trans and v_e were replaced in the images with the corresponding T₂ gray scale value. To enable a comparison to the standard model presented in Figure 3, we included voxels for which v_p > 0 (though only v_p > 0.001 values were included in the statistical analysis. Similar parameter patterns and spatial distributions of high and low values are observed between scans; the degree of agreement is demonstrated in the histograms shown the right column. The top histogram represents the distribution of K^trans values for scan 1 (black bars) and 2 (gray bars). The center panel shows the distribution of v_e for scan 1 (black bars) and scan 2 (gray bars), and the bottom histogram gives the distribution of v_p for scans 1 (black bars) and 2 (gray bars). [Color figure can be viewed in the online issue, which is available at wileyonlinelibrary.com.]