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. Author manuscript; available in PMC: 2014 Jul 2.
Published in final edited form as: Cell Metab. 2013 Jul 2;18(1):51–61. doi: 10.1016/j.cmet.2013.06.010

Figure 1. The miR-96/182/183 locus is directly regulated by SREBP-2.

Figure 1

A). qPCR analysis of miR-96/182/183 in RNA from mice fed chow (N), chow supplemented with cholesterol (Ch), or chow supplemented with lovastatin plus ezetimibe (LE). Samples were normalized to sno202 RNA samples analyzed in parallel. Data are plotted relative to normalized values from chow group set at 1.0. B) ChIP analysis for SREBP-2 binding in hepatic chromatin from cholesterol (Ch) vs. lovastatin/ezetimibe (LE) supplemented mice. The three regions in the miR - 96/182/183 locus that were analyzed for SREBP-2 association are shown by the location of forward (F) and reverse (R) primer pairs 1, 2, or 3 used for the qPCR analysis as indicated. The thick gray box denotes the putative promoter region for the locus interrogated by primer pair 1 as discussed in the text. Data are represented as mean +/− SEM. See also Figure S2.