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. Author manuscript; available in PMC: 2013 Aug 12.
Published in final edited form as: Biochim Biophys Acta. 2011 Dec 19;1818(10):2403–2412. doi: 10.1016/j.bbamem.2011.12.013

Figure 3. Two potential mechanisms exist to explain acute generation of HETE-PLs by LOX oxidation.

Figure 3

Structures in pink represent oxidized fatty acid chains. Panel A. Hydrolysis-dependent formation. PLA2 hydrolysis followed by 12-LOX oxidation, then re-esterification using Fatty acid CoA ligase (FACL), e.g. in neutrophils and platelets. Panel B. Direct membrane oxidation. Direct oxidation of membrane PL by 12/15-LOX, e.g. monocytes/macrophages.