. Author manuscript; available in PMC: 2013 Aug 12.

Published in final edited form as: Biochim Biophys Acta. 2011 Dec 19;1818(10):2403–2412. doi: 10.1016/j.bbamem.2011.12.013

Table 1. Summary of esterified eicosanoids generated by mammalian cells, and their actions, where known.

EXOGENOUS:
Cell Type	Species generated	Function
Epithelial cells	16-, 17-, 18-, 19-, 20- HETE- PE/PS/PI/PC 15-HETE-PI/PE 12-HETE-PI/PE/PC/PS 5-HETE-PE/PC
Endothelial cells	5-HETE-PC 12-HETE-PC 15-HETE-PI 16-, 17-, 18-, 19-, 20- HETE- PE/PS/PI/PC	Inhibits histamine- and arachidonate- stimulated production of PGE2 and 6- ketoPGF1α in human endothelial cells.
Neutrophils	15-HETE-PC/PI
Murine macrophages	15-HETE-PC/PI
Human peripheral blood mononuclear cells	12-HETE-PI
ENDOGENOUS:
Platelets	12-HETE-PE/PC	Enhances coagulation of platelets
Murine macrophages	12-HETE-PE PGE₂-G 2-AG PGH₂-G, which is then converted to PGD₂-G, PGE₂- D, PGF₂α-G and PGI₂-G. PGE2-AEA	Calcium mobilization and activation of the ERK/MAPK pathway. Inhibits LPS/IFNγ-induced IL-12 and IL- 23 expression in microglia and macrophages by reducing expression of IL-12p40.
Human peripheral blood monocytes	15-HETE-PE	Inhibition of LPS-induced G-CSF and TNFα generation my human monocytes. Inhibition of NET formation by neutrophils. Promotes MUC5AC formation by
Neutrophils	5-HETE-PE/PC	Inhibition of NET formation. Enhances IL-8 and superoxide generation by neutrophils.
Leprosy lesions, low density lipoproteins	PC-esterified isoprostanes	Exacerbate leprosy infection Increase MCP-1, IL-8 generation via PPARa in endothelial cells, increase monocyte binding to endothelium.