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. 2013 Jul 22;110(32):13073–13078. doi: 10.1073/pnas.1311861110

Fig. 4.

Fig. 4.

Convergent αEβ7+CD38+CD8+TCRβ CDR3 motifs are found among clones within the same celiac patient and across different patients following gluten challenge. (A and B) Convergent motifs CxxxxGN (A) and CxxxxGT (B) are seen in TCRβ clones using TRBV7-9 and TRBV7-8, respectively. The frequency of each clone is indicated and the total number of T cells sequenced in the patient is indicated in parentheses. The protein sequence with the corresponding DNA sequence is shown. Within the protein sequence, yellow indicates absolutely conserved amino acids, gray indicates relatively conserved (≥50%) amino acids, and blue indicates conserved amino acids that are encoded within the V or J genes. Within the DNA sequence, nucleotides in yellow are formed through N or P addition, whereas nucleotides in gray are encoded by D genes. Boxes around frequency numbers highlight distinct clones sharing identical protein sequences. (C) Convergences of motifs seen in TCRβ clones using TRBV7-9, TRBV7-8, and TRBV28 are statistically significant compared with reference control TCRβ sequences.