Fig. 6.

Trpm7 deletion slows spontaneous AP firing and diastolic depolarization in murine SAN. (A) Spontaneous APs recorded in WT SAN (Upper) and KO^αMHC-Cre SAN (Lower) under basal conditions (Left), 2 nM ISO (Center), and 100 nM ISO (Right). (B) Mean AP firing rate. (C) Representative AP from WT SAN compared with KO^αMHC-Cre SAN showing slowed DDSL in KO^αMHC-Cre SAN. (D) Mean DDSL in WT SAN compared with KO^αMHC-Cre SAN under basal conditions and with 2 nM and 100 nM ISO. *P < 0.05, **P < 0.01.