Fig. 3.

Specific reduction of complex IV assembly leads to mitochondrial hyperfusion. L4 larvae carrying the Pmyo-3:mitoGFP transgene were treated with mock, mma-1, mefg-1, nuaf-1, or sco-1 RNAi and mitochondrial morphology in body-wall muscle cells of L4 larvae of the F1 generation was analyzed by fluorescent microscopy. (A) Schematic of the different mitochondrial morphologies observed. (B) MitoGFP image and schematic of the representative mitochondrial morphology observed as well as quantification are indicated. (n = number of animals analyzed.)