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. 2013 Jul 22;110(32):13156–13161. doi: 10.1073/pnas.1306342110

Fig. 3.

Fig. 3.

PTH2R-KO mice display less spontaneous nocifensive behavior in chronic inflammatory and nerve injury models. Wheel running following hindpaw CFA injection and static hindpaw weight bearing after PNL were compared between WT and PTH2R-KO mice. (A and B) Change in running wheel activity with 1-h daily access following bilateral hindpaw injection of 20 μL of CFA. The distance run by WT decreased significantly for 2 d (A; F5, 25 = 7.5; P < 0.001), whereas the effect of CFA on PTH2R-KO running was not significant (B; F5, 25 = 1.9; P > 0.05). (C and D) Hindpaw static weight bearing following unilateral PNL. Guarding behavior, demonstrated by reduced injured side weight bearing, lasted for 20 d following PNL in WT mice (C; F6, 60 = 2.4; P < 0.05), whereas the PTH2R-KO mice had no weight bearing shift (D). P values in the legend refer to the effect of time in the ANOVA. Symbols above the columns refer to the post hoc test. *P < 0.05, **P < 0.01.