M. tuberculosis strains from South Africa have varying patterns of sulfatase activity. The name of each lineage is color-coded: Euro-American (red; nos. 2576, 405, 1127, 3380, and 198), Indo-Oceanic (pink; no. 1659), East Asian (blue; nos. 2701 and 1125), and India and East Africa (purple; no. 974). Additional strains were evaluated and are shown in SI Appendix, Fig. S7.