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rNTPs decrease the rate of eukaryotic Pol δ and Pol ε holoenzymes. (Upper) The PCNA clamp is loaded onto singly primed ϕX174 ssDNA by the RFC clamp loader, and either Pol δ or Pol ε is added to assemble the Pol δ or Pol ε holoenzyme. Only two dNTPs are present to prevent elongation, and then synchronous synthesis is initiated on adding remaining dNTPs. (Left) Alkaline gel. (Right) Histogram of product lengths observed at 20 s.
