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. Author manuscript; available in PMC: 2014 Apr 1.
Published in final edited form as: Genesis. 2013 Feb 25;51(4):234–245. doi: 10.1002/dvg.22370

Figure 4. Generation of Gad1-Pax5KO and Developmental Phenotype.

Figure 4

(A) Schematic diagram of generation of the Gad1-Pax5KO mice. (B) Morphological appearance of a homozygous Gad1-Cre, Pax5f/f mouse (“KO”) characterized by dome-shaped head, kyphosis and emaciation, compared to a Pax5f/f (“Control”) mouse (postnatal days 35, littermates). (C) Schematic diagram of gene dosage-dependent partial penetrance of the lateral ventricle dilation of the Gad1-Pax5KO (D) Life span and prevalence of hydrocephalus in Gad1-Cre-Pax5-deficient mice.