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IL-6 and sIL-6R protect neuroblastoma cells from drug toxicity. CHLA-255 (A and B) and SK-N-SH cells (C and D) were treated with IL-6 (10 ng/mL) alone or with sIL-6R (25 ng/mL) for 24 hours before being exposed to etoposide (A and C) or melphalan (B and D) at indicated concentrations. Cell viability was determined after 24 hours of drug exposure by DIMSCAN analysis. The data represent the mean (±SD) survival fraction with a minimum of 10 replicates for each experimental condition.
